:root {
  --bg-primary: #0a0e1a;
  --bg-secondary: #111827;
  --bg-card: #151c2e;
  --accent-cyan: #00e5c8;
  --accent-cyan-dim: rgba(0, 229, 200, 0.15);
  --accent-cyan-glow: rgba(0, 229, 200, 0.4);
  --accent-amber: #f5a623;
  --accent-amber-dim: rgba(245, 166, 35, 0.12);
  --accent-violet: #8b5cf6;
  --accent-violet-dim: rgba(139, 92, 246, 0.12);
  --accent-rose: #f43f5e;
  --accent-rose-dim: rgba(244, 63, 94, 0.1);
  --accent-emerald: #10b981;
  --accent-emerald-dim: rgba(16, 185, 129, 0.12);
  --accent-fuchsia: #ec4899;
  --accent-fuchsia-dim: rgba(236, 72, 153, 0.1);
  --text-primary: #e8ecf4;
  --text-secondary: #94a3b8;
  --text-muted: #64748b;
  --border-subtle: rgba(148, 163, 184, 0.08);
  --border-glow: rgba(0, 229, 200, 0.2);
  --font-display: 'Merriweather', 'Noto Serif SC', serif;
  --font-body: system-ui, -apple-system, 'Segoe UI', 'Roboto', 'Noto Sans SC', 'PingFang SC', 'Microsoft YaHei', sans-serif;
  --font-mono: 'Fira Code', 'IBM Plex Mono', monospace;
  --radius-sm: 6px;
  --radius-md: 12px;
  --radius-lg: 20px;
  --shadow-card: 0 4px 24px rgba(0,0,0,0.3), 0 1px 4px rgba(0,0,0,0.2);
  --shadow-glow: 0 0 30px rgba(0, 229, 200, 0.08);
  --transition-fast: 0.2s cubic-bezier(0.4, 0, 0.2, 1);
  --transition-smooth: 0.4s cubic-bezier(0.22, 1, 0.36, 1);
}
[data-theme="light"] {
  --bg-primary: #f0f4f8;
  --bg-secondary: #e2e8f0;
  --bg-card: #ffffff;
  --text-primary: #0f172a;
  --text-secondary: #475569;
  --text-muted: #94a3b8;
  --border-subtle: rgba(0, 0, 0, 0.08);
  --border-glow: rgba(0, 180, 160, 0.35);
  --shadow-card: 0 4px 24px rgba(0,0,0,0.08), 0 1px 4px rgba(0,0,0,0.04);
  --shadow-glow: 0 0 30px rgba(0, 180, 160, 0.12);
}
[data-theme="light"] body::before { opacity: 0.12; }
[data-theme="light"] .grid-bg { opacity: 0.2; }
[data-theme="light"] .top-bar { background: rgba(240,244,248,0.96); }
[data-theme="light"] .header { background: rgba(240,244,248,0.88); }
[data-theme="light"] .header.scrolled { background: rgba(240,244,248,0.98); box-shadow: 0 4px 30px rgba(0,0,0,0.08); }
[data-theme="light"] .search-overlay { background: rgba(240,244,248,0.95); }
[data-theme="light"] .search-box input { background: var(--bg-card); }
[data-theme="light"] .ticker-bar { background: #f1f5f9; border-bottom-color: #e2e8f0; }
[data-theme="light"] .ticker-item { color: #334155; }
[data-theme="light"] .ticker-item:hover { color: #0f172a; }
[data-theme="light"] .ticker-label { background: rgba(0,180,160,0.08); border-right-color: #e2e8f0; }
[data-theme="light"] .ticker-src { color: #64748b; }
[data-theme="light"] .ticker-sep { color: rgba(0,180,160,0.25); }
[data-theme="light"] .site-footer { background: var(--bg-secondary); }
[data-theme="light"] .mobile-nav-panel { background: var(--bg-secondary); }
[data-theme="light"] .hot-rank.normal { background: rgba(0,0,0,0.06); }
[data-theme="light"] .topic-tag { background: rgba(0,0,0,0.04); }
[data-theme="light"] .sub-input { background: rgba(0,0,0,0.05); border-color: rgba(0,0,0,0.12); }
*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }
html { scroll-behavior: smooth; -webkit-font-smoothing: antialiased; -moz-osx-font-smoothing: grayscale; text-rendering: optimizeLegibility; }
body { font-family: var(--font-body); background: var(--bg-primary); color: var(--text-primary); line-height: 1.8; overflow-x: hidden; transition: background 0.3s, color 0.3s; letter-spacing: 0.015em; word-spacing: 0.05em; }
/* 中文段落排版全局规范 */
p, .body-text {
  text-align: justify;
  text-justify: auto;
  overflow-wrap: break-word;
  word-break: keep-all;
  hyphens: none;
  orphans: 3;
  widows: 3;
}
h1,h2,h3,h4,h5,h6 { text-align: left; letter-spacing: -0.02em; }
a { text-decoration: none; color: inherit; }
button { cursor: pointer; border: none; background: none; font-family: inherit; }
body::before { content: ''; position: fixed; inset: 0; background: radial-gradient(ellipse 80% 60% at 20% 10%, rgba(0,229,200,0.04) 0%, transparent 60%), radial-gradient(ellipse 60% 50% at 80% 80%, rgba(139,92,246,0.03) 0%, transparent 60%); pointer-events: none; z-index: 0; }
.grid-bg { position: fixed; inset: 0; background-image: linear-gradient(rgba(148,163,184,0.03) 1px, transparent 1px), linear-gradient(90deg, rgba(148,163,184,0.03) 1px, transparent 1px); background-size: 60px 60px; pointer-events: none; z-index: 0; }
.container { max-width: 1360px; margin: 0 auto; padding: 0 24px; position: relative; z-index: 1; }

.top-bar { background: rgba(10,14,26,0.92); backdrop-filter: blur(20px); border-bottom: 1px solid var(--border-subtle); padding: 8px 0; font-size: 12px; color: var(--text-muted); position: relative; z-index: 100; transition: background 0.3s; }
.top-bar .container { display: flex; justify-content: space-between; align-items: center; flex-wrap: wrap; gap: 8px; }
.top-bar-left { display: flex; align-items: center; gap: 16px; }
.top-bar-left .date { font-family: var(--font-mono); letter-spacing: 0.5px; }
.live-dot { width: 6px; height: 6px; border-radius: 50%; background: var(--accent-cyan); animation: pulse-dot 2s ease-in-out infinite; display: inline-block; }
@keyframes pulse-dot { 0%,100% { opacity:1; box-shadow:0 0 4px var(--accent-cyan); } 50% { opacity:0.4; box-shadow:none; } }
.top-bar-right { display: flex; align-items: center; gap: 16px; }
.top-bar-right a { color: var(--text-muted); transition: color var(--transition-fast); }
.top-bar-right a:hover { color: var(--accent-cyan); }

.header { position: sticky; top: 0; z-index: 999; background: rgba(10,14,26,0.85); backdrop-filter: blur(24px) saturate(180%); border-bottom: 1px solid var(--border-subtle); transition: all var(--transition-smooth); }
.header.scrolled { background: rgba(10,14,26,0.95); box-shadow: 0 4px 30px rgba(0,0,0,0.3); }
.header .container { display: flex; align-items: center; justify-content: space-between; height: 72px; }
.logo { display: flex; align-items: center; gap: 12px; flex-shrink: 0; }
.logo-icon { width: 42px; height: 42px; border-radius: var(--radius-md); background: linear-gradient(135deg, var(--accent-cyan), var(--accent-violet)); display: flex; align-items: center; justify-content: center; font-size: 18px; font-weight: 800; color: var(--bg-primary); font-family: var(--font-mono); position: relative; overflow: hidden; }
.logo-icon::after { content: ''; position: absolute; inset: 0; background: linear-gradient(135deg, transparent 40%, rgba(255,255,255,0.2)); }
.logo-text h1 { font-family: var(--font-display); font-size: 22px; font-weight: 800; background: linear-gradient(135deg, var(--text-primary) 60%, var(--accent-cyan)); -webkit-background-clip: text; -webkit-text-fill-color: transparent; line-height: 1.2; }
.logo-text span { font-size: 11px; color: var(--text-muted); letter-spacing: 2px; text-transform: uppercase; font-weight: 500; }
.main-nav { display: flex; align-items: center; gap: 2px; }
.main-nav a { padding: 7px 11px; font-size: 13px; font-weight: 500; color: var(--text-secondary); border-radius: var(--radius-sm); transition: all var(--transition-fast); white-space: nowrap; position: relative; }
.main-nav a:hover { color: var(--text-primary); background: rgba(255,255,255,0.04); }
.main-nav a.active, .main-nav a.nav-active { color: var(--accent-cyan); background: var(--accent-cyan-dim); }
.main-nav a.nav-active::after { content: ''; position: absolute; bottom: -1px; left: 50%; transform: translateX(-50%); width: 16px; height: 2px; border-radius: 1px; background: var(--accent-cyan); }
.header-actions { display: flex; align-items: center; gap: 6px; }
.icon-btn { width: 40px; height: 40px; border-radius: var(--radius-sm); display: flex; align-items: center; justify-content: center; color: var(--text-secondary); transition: all var(--transition-fast); }
.icon-btn:hover { color: var(--text-primary); background: rgba(255,255,255,0.06); }
.icon-btn svg { width: 18px; height: 18px; }
.icon-btn.theme { font-size: 17px; }
.icon-btn.menu { display: none; font-size: 20px; }
.refresh-btn { padding: 8px 18px; font-size: 13px; font-weight: 600; color: var(--bg-primary); background: var(--accent-cyan); border-radius: var(--radius-sm); transition: all var(--transition-fast); }
.refresh-btn:hover { background: #00ffdc; box-shadow: 0 0 20px var(--accent-cyan-glow); transform: translateY(-1px); }
.refresh-btn:disabled { opacity: 0.6; cursor: wait; transform: none; }

/* Mobile Nav */
.mobile-nav { position: fixed; inset: 0; z-index: 9997; pointer-events: none; }
.mobile-nav.open { pointer-events: all; }
.mobile-nav-backdrop { position: absolute; inset: 0; background: rgba(0,0,0,0.65); opacity: 0; transition: opacity 0.3s; }
.mobile-nav.open .mobile-nav-backdrop { opacity: 1; }
.mobile-nav-panel { position: absolute; top: 0; left: 0; width: 280px; height: 100%; background: var(--bg-secondary); border-right: 1px solid var(--border-subtle); padding: 20px; transform: translateX(-100%); transition: transform 0.35s cubic-bezier(0.22,1,0.36,1); display: flex; flex-direction: column; gap: 4px; overflow-y: auto; }
.mobile-nav.open .mobile-nav-panel { transform: translateX(0); }
.mobile-nav-close { align-self: flex-end; width: 36px; height: 36px; display: flex; align-items: center; justify-content: center; font-size: 18px; color: var(--text-muted); border-radius: var(--radius-sm); margin-bottom: 12px; flex-shrink: 0; }
.mobile-nav-panel a { padding: 11px 14px; border-radius: var(--radius-sm); color: var(--text-secondary); font-size: 14px; font-weight: 500; transition: all var(--transition-fast); display: block; }
.mobile-nav-panel a:hover, .mobile-nav-panel a.mob-active { color: var(--accent-cyan); background: var(--accent-cyan-dim); }
.mobile-nav-divider { height: 1px; background: var(--border-subtle); margin: 8px 0; flex-shrink: 0; }

/* Search */
.search-overlay { position: fixed; inset: 0; z-index: 9999; background: rgba(10,14,26,0.92); backdrop-filter: blur(30px); display: flex; align-items: flex-start; justify-content: center; padding-top: 160px; opacity: 0; pointer-events: none; transition: opacity 0.3s ease; }
.search-overlay.active { opacity: 1; pointer-events: all; }
.search-box { width: 680px; max-width: 90vw; position: relative; transform: translateY(20px); transition: transform 0.4s cubic-bezier(0.22,1,0.36,1); }
.search-overlay.active .search-box { transform: translateY(0); }
.search-box input { width: 100%; padding: 20px 60px 20px 24px; font-size: 20px; font-family: var(--font-body); background: var(--bg-card); border: 1px solid var(--border-glow); border-radius: var(--radius-lg); color: var(--text-primary); outline: none; box-shadow: var(--shadow-glow); }
.search-box input::placeholder { color: var(--text-muted); }
.search-close { position: absolute; right: 16px; top: 22px; width: 36px; height: 36px; border-radius: var(--radius-sm); display: flex; align-items: center; justify-content: center; color: var(--text-muted); font-size: 11px; font-family: var(--font-mono); background: rgba(255,255,255,0.06); }
.search-results { margin-top: 12px; max-height: 400px; overflow-y: auto; }
.search-result-item { display: block; padding: 12px 16px; border-radius: var(--radius-sm); transition: background var(--transition-fast); }
.search-result-item:hover { background: rgba(255,255,255,0.04); }
.search-result-item h4 { font-size: 14px; font-weight: 600; margin-bottom: 4px; color: var(--text-primary); }
.search-result-item p { font-size: 12px; color: var(--text-muted); }

/* Ticker */
.ticker-bar { background: rgba(6,10,20,0.96); border-bottom: 1px solid rgba(0,229,200,0.1); overflow: hidden; height: 44px; display: flex; align-items: center; position: relative; z-index: 10; transition: background 0.3s; }
.ticker-label { flex-shrink: 0; padding: 0 16px; font-size: 11px; font-weight: 800; letter-spacing: 1.5px; color: var(--accent-cyan); border-right: 1px solid rgba(0,229,200,0.15); height: 100%; display: flex; align-items: center; background: rgba(0,229,200,0.08); gap: 8px; }
.ticker-label::before { content: ''; width: 7px; height: 7px; border-radius: 50%; background: var(--accent-cyan); animation: pulse-dot 2s ease-in-out infinite; box-shadow: 0 0 8px var(--accent-cyan); }
@keyframes pulse-dot { 0%,100% { opacity: 1; transform: scale(1); } 50% { opacity: 0.4; transform: scale(0.75); } }
.ticker-track { display: flex; animation: ticker-scroll 120s linear infinite; white-space: nowrap; }
.ticker-track:hover { animation-play-state: paused; }
.ticker-item { display: inline-flex; align-items: center; gap: 8px; padding: 0 20px; font-size: 12.5px; color: #cdd5e0; cursor: pointer; transition: color var(--transition-fast); white-space: nowrap; height: 44px; line-height: 44px; }
.ticker-item:hover { color: #ffffff; }
.ticker-sep { color: rgba(0,229,200,0.2); font-size: 14px; flex-shrink: 0; user-select: none; }
.ticker-tag { font-size: 10px; padding: 2px 7px; border-radius: 3px; font-weight: 700; letter-spacing: 0.3px; flex-shrink: 0; }
.ticker-tag.drug { background: var(--accent-cyan-dim); color: var(--accent-cyan); }
.ticker-tag.protein { background: var(--accent-violet-dim); color: var(--accent-violet); }
.ticker-tag.genomics { background: var(--accent-amber-dim); color: var(--accent-amber); }
.ticker-tag.clinical { background: var(--accent-rose-dim); color: var(--accent-rose); }
.ticker-tag.cell { background: rgba(34,197,94,0.12); color: #22c55e; }
.ticker-tag.imaging { background: rgba(59,130,246,0.12); color: #3b82f6; }
.ticker-tag.synbio { background: var(--accent-emerald-dim); color: var(--accent-emerald); }
.ticker-tag.neuro { background: var(--accent-fuchsia-dim); color: var(--accent-fuchsia); }
.ticker-title { max-width: 380px; overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }
.ticker-src { font-size: 10px; color: #7a8ba3; opacity: 1; flex-shrink: 0; margin-left: 2px; }
.ticker-item .hot-badge { font-size: 9px; padding: 2px 6px; border-radius: 3px; background: var(--accent-rose); color: white; font-weight: 700; letter-spacing: 0.5px; flex-shrink: 0; }
@keyframes ticker-scroll { 0% { transform: translateX(0); } 100% { transform: translateX(-50%); } }

/* Hero */
.hero-section { padding: 32px 0 0; position: relative; z-index: 1; }
.hero-grid { display: grid; grid-template-columns: 1fr; gap: 20px; min-height: 480px; }
.hero-main { position: relative; border-radius: var(--radius-lg); overflow: hidden; background: var(--bg-card); cursor: pointer; min-height: 480px; }
.hero-slide { position: absolute; inset: 0; opacity: 0; pointer-events: none; transition: opacity 0.9s ease; }
.hero-slide.active { opacity: 1; pointer-events: all; z-index: 2; }
.hero-slide-grid { display: grid; grid-template-columns: 1fr 1fr; height: 100%; }
.hero-article { position: relative; overflow: hidden; }
.hero-article-bg { position: absolute; inset: 0; transition: transform 8s ease-out; }
.hero-article-bg img { width: 100%; height: 100%; object-fit: cover; display: block; }
.hero-slide.active .hero-article-bg { transform: scale(1.05); }
.hero-article-overlay { position: absolute; inset: 0; background: linear-gradient(to bottom, rgba(10,14,26,0.9) 0%, rgba(10,14,26,0.7) 35%, rgba(10,14,26,0.3) 65%, rgba(10,14,26,0.1) 100%); }
.hero-article-content { position: relative; z-index: 2; padding: 32px 28px 24px; display: flex; flex-direction: column; height: 100%; box-sizing: border-box; }
.hero-article-divider { width: 1px; background: linear-gradient(180deg, transparent 10%, rgba(255,255,255,0.08) 50%, transparent 90%); z-index: 3; }
.hero-tag { display: inline-flex; padding: 4px 12px; font-size: 11px; font-weight: 700; text-transform: uppercase; letter-spacing: 1.2px; border-radius: 4px; margin-bottom: 12px; backdrop-filter: blur(8px); align-self: flex-start; }
.hero-tag.drug { background: var(--accent-cyan-dim); color: var(--accent-cyan); }
.hero-tag.protein { background: var(--accent-violet-dim); color: var(--accent-violet); }
.hero-tag.genomics { background: var(--accent-amber-dim); color: var(--accent-amber); }
.hero-tag.clinical { background: var(--accent-rose-dim); color: var(--accent-rose); }
.hero-tag.cell { background: rgba(34,197,94,0.12); color: #22c55e; }
.hero-tag.imaging { background: rgba(59,130,246,0.12); color: #3b82f6; }
.hero-tag.synbio { background: var(--accent-emerald-dim); color: var(--accent-emerald); }
.hero-tag.neuro { background: var(--accent-fuchsia-dim); color: var(--accent-fuchsia); }
.hero-article-content h2 { font-family: var(--font-display); font-size: 22px; font-weight: 800; line-height: 1.4; margin-bottom: 10px; text-shadow: 0 2px 16px rgba(0,0,0,0.6); letter-spacing: -0.02em; text-align: left; }
.hero-article-content p { font-size: 13px; color: rgba(232,236,244,0.85); line-height: 1.8; display: -webkit-box; -webkit-line-clamp: 5; -webkit-box-orient: vertical; overflow: hidden; letter-spacing: 0.01em; flex: 1; }
.hero-meta { display: flex; align-items: center; gap: 16px; margin-top: 16px; font-size: 12px; color: var(--text-muted); }
.hero-meta .source { color: var(--accent-cyan); font-weight: 600; letter-spacing: 0.3px; }
.hero-dots { position: absolute; bottom: 20px; right: 24px; display: flex; gap: 6px; align-items: center; z-index: 5; }
.hero-dot { width: 28px; height: 3px; border-radius: 2px; background: rgba(255,255,255,0.25); cursor: pointer; transition: all var(--transition-smooth); }
.hero-dot.active { background: var(--accent-cyan); width: 44px; box-shadow: 0 0 10px var(--accent-cyan-glow); }
.hero-sidebar { display: flex; flex-direction: column; gap: 12px; }
.hero-side-card { flex: 1; border-radius: var(--radius-md); overflow: hidden; position: relative; background: var(--bg-card); cursor: pointer; transition: all var(--transition-smooth); min-height: 148px; border: 1px solid var(--border-subtle); display: flex; flex-direction: column; }
.hero-side-card:hover { transform: translateY(-3px); box-shadow: 0 8px 32px rgba(0,0,0,0.3), var(--shadow-glow); border-color: var(--border-glow); }
.hero-side-card-bg { position: absolute; inset: 0; }
.hero-side-card-bg img { width: 100%; height: 100%; object-fit: cover; }
.hero-side-card-overlay { position: absolute; inset: 0; background: linear-gradient(180deg, rgba(10,14,26,0.3) 0%, rgba(10,14,26,0.92) 65%, rgba(10,14,26,0.97) 100%); }
.hero-side-card-content { padding: 18px 20px 20px; flex: 1; display: flex; flex-direction: column; justify-content: flex-end; position: relative; z-index: 2; }
.hero-side-card-content h3 { font-family: var(--font-display); font-size: 14px; font-weight: 700; line-height: 1.55; margin-bottom: 6px; letter-spacing: -0.01em; text-align: left; transition: color var(--transition-fast); }
.hero-side-card-content .side-desc { font-size: 12px; color: rgba(232,236,244,0.7); line-height: 1.7; display: -webkit-box; -webkit-line-clamp: 2; -webkit-box-orient: vertical; overflow: hidden; margin-bottom: 6px; }
.hero-side-card:hover h3 { color: var(--accent-cyan); }
.hero-side-card-content .meta { font-size: 11px; color: var(--text-muted); letter-spacing: 0.02em; margin-top: 10px; }

/* Category */
.category-section { padding: 40px 0 0; }
.section-header { display: flex; align-items: center; justify-content: space-between; margin-bottom: 24px; }
.section-title { font-family: var(--font-display); font-size: 24px; font-weight: 800; display: flex; align-items: center; gap: 12px; letter-spacing: -0.3px; }
.section-title .accent-line { width: 4px; height: 26px; border-radius: 2px; background: linear-gradient(180deg, var(--accent-cyan), var(--accent-violet)); box-shadow: 0 0 10px rgba(0,229,200,0.3); }
/* ── Category filter bar ── */
.category-tabs { display: flex; gap: 10px; margin-bottom: 32px; overflow-x: auto; scrollbar-width: none; padding: 4px 2px 8px; }
.category-tabs::-webkit-scrollbar { display: none; }
.cat-tab {
  display: flex; align-items: center; gap: 8px;
  padding: 9px 18px; border-radius: 10px; cursor: pointer;
  font-size: 13px; font-weight: 600; white-space: nowrap;
  border: 1px solid transparent;
  transition: all 0.22s cubic-bezier(0.4,0,0.2,1);
  position: relative; overflow: hidden;
  background: var(--bg-card);
}
.cat-tab::before {
  content: ''; position: absolute; inset: 0;
  opacity: 0; transition: opacity 0.22s;
}
.cat-tab:hover::before { opacity: 1; }
.cat-tab:hover { transform: translateY(-2px); }
.cat-tab .ct-count {
  font-size: 10px; font-weight: 700; padding: 1px 6px;
  border-radius: 8px; opacity: 0.85; font-family: var(--font-mono);
  transition: all 0.22s;
}
/* all */
.cat-tab[data-cat="all"] { color: var(--text-secondary); border-color: var(--border-subtle); }
.cat-tab[data-cat="all"]::before { background: rgba(255,255,255,0.04); }
.cat-tab[data-cat="all"] .ct-count { background: rgba(255,255,255,0.08); color: var(--text-muted); }
.cat-tab[data-cat="all"].active { color: #fff; background: #1e2a3a; border-color: rgba(255,255,255,0.2); box-shadow: 0 4px 20px rgba(0,0,0,0.4); }
/* drug – cyan */
.cat-tab[data-cat="drug"] { color: var(--accent-cyan); border-color: rgba(0,229,200,0.2); }
.cat-tab[data-cat="drug"]::before { background: rgba(0,229,200,0.06); }
.cat-tab[data-cat="drug"] .ct-count { background: rgba(0,229,200,0.15); color: var(--accent-cyan); }
.cat-tab[data-cat="drug"].active { background: rgba(0,229,200,0.12); border-color: rgba(0,229,200,0.5); box-shadow: 0 4px 24px rgba(0,229,200,0.2), inset 0 1px 0 rgba(0,229,200,0.15); }
/* protein – violet */
.cat-tab[data-cat="protein"] { color: var(--accent-violet); border-color: rgba(139,92,246,0.2); }
.cat-tab[data-cat="protein"]::before { background: rgba(139,92,246,0.06); }
.cat-tab[data-cat="protein"] .ct-count { background: rgba(139,92,246,0.15); color: var(--accent-violet); }
.cat-tab[data-cat="protein"].active { background: rgba(139,92,246,0.12); border-color: rgba(139,92,246,0.5); box-shadow: 0 4px 24px rgba(139,92,246,0.2), inset 0 1px 0 rgba(139,92,246,0.15); }
/* genomics – amber */
.cat-tab[data-cat="genomics"] { color: var(--accent-amber); border-color: rgba(245,166,35,0.2); }
.cat-tab[data-cat="genomics"]::before { background: rgba(245,166,35,0.06); }
.cat-tab[data-cat="genomics"] .ct-count { background: rgba(245,166,35,0.15); color: var(--accent-amber); }
.cat-tab[data-cat="genomics"].active { background: rgba(245,166,35,0.1); border-color: rgba(245,166,35,0.5); box-shadow: 0 4px 24px rgba(245,166,35,0.2), inset 0 1px 0 rgba(245,166,35,0.15); }
/* clinical – rose */
.cat-tab[data-cat="clinical"] { color: var(--accent-rose); border-color: rgba(244,63,94,0.2); }
.cat-tab[data-cat="clinical"]::before { background: rgba(244,63,94,0.06); }
.cat-tab[data-cat="clinical"] .ct-count { background: rgba(244,63,94,0.15); color: var(--accent-rose); }
.cat-tab[data-cat="clinical"].active { background: rgba(244,63,94,0.1); border-color: rgba(244,63,94,0.5); box-shadow: 0 4px 24px rgba(244,63,94,0.2), inset 0 1px 0 rgba(244,63,94,0.12); }
/* cell – green */
.cat-tab[data-cat="cell"] { color: #22c55e; border-color: rgba(34,197,94,0.2); }
.cat-tab[data-cat="cell"]::before { background: rgba(34,197,94,0.06); }
.cat-tab[data-cat="cell"] .ct-count { background: rgba(34,197,94,0.15); color: #22c55e; }
.cat-tab[data-cat="cell"].active { background: rgba(34,197,94,0.1); border-color: rgba(34,197,94,0.5); box-shadow: 0 4px 24px rgba(34,197,94,0.2), inset 0 1px 0 rgba(34,197,94,0.12); }
/* imaging – blue */
.cat-tab[data-cat="imaging"] { color: #3b82f6; border-color: rgba(59,130,246,0.2); }
.cat-tab[data-cat="imaging"]::before { background: rgba(59,130,246,0.06); }
.cat-tab[data-cat="imaging"] .ct-count { background: rgba(59,130,246,0.15); color: #3b82f6; }
.cat-tab[data-cat="imaging"].active { background: rgba(59,130,246,0.1); border-color: rgba(59,130,246,0.5); box-shadow: 0 4px 24px rgba(59,130,246,0.2), inset 0 1px 0 rgba(59,130,246,0.12); }
/* synbio – emerald */
.cat-tab[data-cat="synbio"] { color: var(--accent-emerald); border-color: rgba(16,185,129,0.2); }
.cat-tab[data-cat="synbio"]::before { background: rgba(16,185,129,0.06); }
.cat-tab[data-cat="synbio"] .ct-count { background: rgba(16,185,129,0.15); color: var(--accent-emerald); }
.cat-tab[data-cat="synbio"].active { background: rgba(16,185,129,0.1); border-color: rgba(16,185,129,0.5); box-shadow: 0 4px 24px rgba(16,185,129,0.2), inset 0 1px 0 rgba(16,185,129,0.12); }
/* neuro – fuchsia */
.cat-tab[data-cat="neuro"] { color: var(--accent-fuchsia); border-color: rgba(236,72,153,0.2); }
.cat-tab[data-cat="neuro"]::before { background: rgba(236,72,153,0.06); }
.cat-tab[data-cat="neuro"] .ct-count { background: rgba(236,72,153,0.15); color: var(--accent-fuchsia); }
.cat-tab[data-cat="neuro"].active { background: rgba(236,72,153,0.1); border-color: rgba(236,72,153,0.5); box-shadow: 0 4px 24px rgba(236,72,153,0.2), inset 0 1px 0 rgba(236,72,153,0.12); }
.content-layout { display: grid; grid-template-columns: 1fr 340px; gap: 32px; padding-bottom: 60px; align-items: stretch; }

/* News cards — text-first, no broken image area */
.news-grid { display: grid; grid-template-columns: repeat(2, 1fr); gap: 16px; min-height: 400px; }
.news-grid > .news-card:last-child:nth-child(odd) { grid-column: 1 / -1; }
.news-card { background: var(--bg-card); border-radius: var(--radius-md); overflow: hidden; border: 1px solid var(--border-subtle); border-left: 3px solid transparent; transition: all var(--transition-smooth); cursor: pointer; display: flex; flex-direction: column; }
.news-card:hover { transform: translateY(-3px); box-shadow: 0 8px 32px rgba(0,0,0,0.3); }
.news-card-body { padding: 20px 22px; flex: 1; display: flex; flex-direction: column; }
.news-card-tag { display: inline-block; padding: 3px 9px; font-size: 10px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.8px; border-radius: 3px; margin-bottom: 10px; width: fit-content; }
.tag-drug { background: var(--accent-cyan-dim); color: var(--accent-cyan); }
.nc-drug { border-left-color: var(--accent-cyan); }
.nc-drug:hover { border-left-color: var(--accent-cyan); box-shadow: 0 8px 32px rgba(0,0,0,0.3), -2px 0 12px rgba(0,229,200,0.15); }
.tag-protein { background: var(--accent-violet-dim); color: var(--accent-violet); }
.nc-protein { border-left-color: var(--accent-violet); }
.nc-protein:hover { box-shadow: 0 8px 32px rgba(0,0,0,0.3), -2px 0 12px rgba(139,92,246,0.15); }
.tag-genomics { background: var(--accent-amber-dim); color: var(--accent-amber); }
.nc-genomics { border-left-color: var(--accent-amber); }
.nc-genomics:hover { box-shadow: 0 8px 32px rgba(0,0,0,0.3), -2px 0 12px rgba(245,166,35,0.15); }
.tag-clinical { background: var(--accent-rose-dim); color: var(--accent-rose); }
.nc-clinical { border-left-color: var(--accent-rose); }
.nc-clinical:hover { box-shadow: 0 8px 32px rgba(0,0,0,0.3), -2px 0 12px rgba(244,63,94,0.15); }
.tag-cell { background: rgba(34,197,94,0.12); color: #22c55e; }
.nc-cell { border-left-color: #22c55e; }
.nc-cell:hover { box-shadow: 0 8px 32px rgba(0,0,0,0.3), -2px 0 12px rgba(34,197,94,0.15); }
.tag-imaging { background: rgba(59,130,246,0.12); color: #3b82f6; }
.nc-imaging { border-left-color: #3b82f6; }
.nc-imaging:hover { box-shadow: 0 8px 32px rgba(0,0,0,0.3), -2px 0 12px rgba(59,130,246,0.15); }
.tag-synbio { background: var(--accent-emerald-dim); color: var(--accent-emerald); }
.nc-synbio { border-left-color: var(--accent-emerald); }
.nc-synbio:hover { box-shadow: 0 8px 32px rgba(0,0,0,0.3), -2px 0 12px rgba(16,185,129,0.15); }
.tag-neuro { background: var(--accent-fuchsia-dim); color: var(--accent-fuchsia); }
.nc-neuro { border-left-color: var(--accent-fuchsia); }
.nc-neuro:hover { box-shadow: 0 8px 32px rgba(0,0,0,0.3), -2px 0 12px rgba(236,72,153,0.15); }
.news-card-body h3 { font-family: var(--font-display); font-size: 15.5px; font-weight: 700; line-height: 1.5; margin-bottom: 8px; transition: color var(--transition-fast); letter-spacing: -0.01em; text-align: left; }
.news-card:hover h3 { color: var(--accent-cyan); }
.news-card-body p { font-size: 13px; color: var(--text-secondary); line-height: 1.85; flex: 1; display: -webkit-box; -webkit-line-clamp: 5; -webkit-box-orient: vertical; overflow: hidden; letter-spacing: 0.01em; text-align: justify; text-justify: inter-character; }
.news-card-footer { display: flex; align-items: center; justify-content: space-between; margin-top: 14px; padding-top: 11px; border-top: 1px solid var(--border-subtle); font-size: 11px; color: var(--text-muted); }
.news-card-footer .author { font-weight: 600; font-size: 11px; }
/* Featured: full-width top card with accent banner */
.news-card.featured { grid-column: 1 / -1; border-left-width: 3px; }
.news-card.featured .news-card-body { padding: 28px 28px 24px; }
.news-card.featured h3 { font-size: 20px; line-height: 1.4; margin-bottom: 10px; }
.news-card.featured p { -webkit-line-clamp: 4; font-size: 14px; }
.featured-banner { height: 6px; width: 100%; background: linear-gradient(90deg, var(--accent-cyan), var(--accent-violet), var(--accent-amber)); opacity: 0.7; }

/* Sidebar */
.sidebar { display: flex; flex-direction: column; justify-content: flex-start; gap: 28px; }
.sidebar-block { background: var(--bg-card); border-radius: var(--radius-md); border: 1px solid var(--border-subtle); overflow: hidden; }
.sidebar-block-header { padding: 16px 20px; font-size: 14px; font-weight: 700; display: flex; align-items: center; gap: 8px; border-bottom: 1px solid var(--border-subtle); }
.hot-list { padding: 8px 0; }
.hot-item { display: flex; align-items: flex-start; gap: 12px; padding: 11px 20px; transition: all var(--transition-fast); cursor: pointer; border-left: 2px solid transparent; }
.hot-item:hover { background: rgba(0,229,200,0.03); border-left-color: rgba(0,229,200,0.3); }
.hot-rank { width: 24px; height: 24px; border-radius: 6px; display: flex; align-items: center; justify-content: center; font-size: 12px; font-weight: 700; flex-shrink: 0; font-family: var(--font-mono); }
.hot-rank.top { background: linear-gradient(135deg, var(--accent-amber), #ff6b35); color: var(--bg-primary); box-shadow: 0 2px 8px rgba(245,166,35,0.3); }
.hot-rank.normal { background: rgba(255,255,255,0.05); color: var(--text-muted); }
.hot-item-text h4 { font-size: 13px; font-weight: 600; line-height: 1.6; margin-bottom: 3px; letter-spacing: 0.005em; text-align: left; }
.hot-item:hover h4 { color: var(--accent-cyan); }
.hot-item-text .views { font-size: 11px; color: var(--text-muted); letter-spacing: 0.02em; }
.topic-cloud { padding: 16px 20px; display: flex; flex-wrap: wrap; gap: 8px; }
.topic-tag { padding: 5px 13px; font-size: 12px; border-radius: 20px; background: rgba(255,255,255,0.04); color: var(--text-secondary); border: 1px solid var(--border-subtle); cursor: pointer; transition: all var(--transition-fast); }
.topic-tag:hover { background: var(--accent-cyan-dim); color: var(--accent-cyan); border-color: rgba(0,229,200,0.35); transform: translateY(-1px); box-shadow: 0 3px 10px rgba(0,229,200,0.1); }
.weekly-card { padding: 24px 20px; position: relative; overflow: hidden; }
.weekly-card::before { content: ''; position: absolute; inset: 0; background: linear-gradient(135deg, var(--accent-cyan-dim), var(--accent-violet-dim)); opacity: 0.5; }
.weekly-card > * { position: relative; z-index: 1; }
.weekly-card h4 { font-family: var(--font-display); font-size: 18px; font-weight: 700; margin-bottom: 8px; }
.weekly-card p { font-size: 13px; color: var(--text-secondary); margin-bottom: 16px; line-height: 1.6; }
.sub-form { display: flex; gap: 8px; }
.sub-input { flex: 1; min-width: 0; padding: 9px 12px; background: rgba(255,255,255,0.06); border: 1px solid var(--border-subtle); border-radius: var(--radius-sm); color: var(--text-primary); font-size: 12px; font-family: var(--font-body); outline: none; transition: border-color var(--transition-fast); }
.sub-input:focus { border-color: var(--border-glow); }
.sub-input::placeholder { color: var(--text-muted); }
.btn-sub { padding: 9px 18px; font-size: 13px; font-weight: 600; color: var(--bg-primary); background: var(--accent-cyan); border-radius: var(--radius-sm); transition: all var(--transition-fast); white-space: nowrap; flex-shrink: 0; }
.btn-sub:hover { background: #00ffdc; box-shadow: 0 0 20px var(--accent-cyan-glow); }
.btn-refresh-sm { display: block; margin-top: 12px; font-size: 12px; color: var(--text-muted); text-align: center; cursor: pointer; transition: color var(--transition-fast); }
.btn-refresh-sm:hover { color: var(--accent-cyan); }

/* Sources */
.sources-section { padding: 48px 0; }
.sources-banner { background: var(--bg-card); border: 1px solid var(--border-subtle); border-radius: var(--radius-lg); padding: 40px; position: relative; overflow: hidden; }
.sources-banner::before { content: ''; position: absolute; top: 0; right: 0; width: 50%; height: 100%; background: linear-gradient(135deg, transparent 30%, var(--accent-cyan-dim)); opacity: 0.6; }
.sources-banner > * { position: relative; z-index: 1; }
.sources-banner h2 { font-family: var(--font-display); font-size: 26px; font-weight: 800; margin-bottom: 14px; letter-spacing: -0.02em; }
.sources-banner > p { color: var(--text-secondary); margin-bottom: 28px; line-height: 1.9; font-size: 14px; letter-spacing: 0.02em; text-align: justify; word-break: normal; overflow-wrap: break-word; }
.source-chips { display: flex; flex-wrap: wrap; gap: 10px; }
.source-chip { display: inline-flex; align-items: center; gap: 8px; padding: 8px 16px; background: rgba(255,255,255,0.03); border: 1px solid var(--border-subtle); border-radius: 20px; font-size: 13px; color: var(--text-secondary); }
.source-chip .dot { width: 8px; height: 8px; border-radius: 50%; flex-shrink: 0; }

/* Footer */
.site-footer { background: var(--bg-secondary); border-top: 1px solid var(--border-subtle); padding: 48px 0 24px; position: relative; z-index: 1; transition: background 0.3s; }
.footer-grid { display: grid; grid-template-columns: 1.5fr 1fr 1fr 1fr; gap: 40px; margin-bottom: 40px; }
.footer-brand h3 { font-family: var(--font-display); font-size: 20px; font-weight: 800; margin-bottom: 12px; background: linear-gradient(135deg, var(--text-primary), var(--accent-cyan)); -webkit-background-clip: text; -webkit-text-fill-color: transparent; }
.footer-brand p { font-size: 13px; color: var(--text-muted); line-height: 1.85; max-width: 300px; letter-spacing: 0.01em; text-align: justify; text-justify: inter-character; }
.footer-col h4 { font-size: 11px; font-weight: 700; text-transform: uppercase; letter-spacing: 2px; color: var(--text-secondary); margin-bottom: 16px; }
.footer-col a { display: block; font-size: 13px; color: var(--text-muted); padding: 5px 0; transition: color var(--transition-fast); line-height: 1.5; }
.footer-col a:hover { color: var(--accent-cyan); }
.footer-bottom { padding-top: 24px; border-top: 1px solid var(--border-subtle); display: flex; align-items: center; justify-content: space-between; font-size: 12px; color: var(--text-muted); }

/* Utils */
.skeleton { background: linear-gradient(90deg, var(--bg-card) 25%, rgba(255,255,255,0.04) 50%, var(--bg-card) 75%); background-size: 200% 100%; animation: shimmer 1.5s infinite; border-radius: var(--radius-sm); }
@keyframes shimmer { 0% { background-position: 200% 0; } 100% { background-position: -200% 0; } }
.fade-in { opacity: 0; transform: translateY(24px); transition: opacity 0.7s ease, transform 0.7s cubic-bezier(0.22,1,0.36,1); }
.fade-in.visible { opacity: 1; transform: translateY(0); }

/* Responsive */
@media (max-width: 1200px) { .main-nav a { padding: 7px 9px; font-size: 12px; } }
@media (max-width: 1024px) {
  .hero-slide-grid { grid-template-columns: 1fr; }
  .hero-article-divider { display: none; }
  .hero-main { min-height: 400px; }
  .content-layout { grid-template-columns: 1fr; }
  .sidebar { display: grid; grid-template-columns: repeat(2, 1fr); }
  .footer-grid { grid-template-columns: repeat(2, 1fr); }
}
@media (max-width: 768px) {
  .news-grid { gap: 12px; }
  .news-grid { grid-template-columns: 1fr; }
  .sidebar { grid-template-columns: 1fr; }
  .hero-article-content h2 { font-size: 20px; }
  .hero-article-content { padding: 24px; }
  .main-nav { display: none; }
  .icon-btn.menu { display: flex; }
  .footer-grid { grid-template-columns: 1fr; gap: 24px; }
  .sources-banner { padding: 24px; }
  .container { padding: 0 16px; }
  .refresh-btn { padding: 8px 12px; font-size: 12px; }
}
@media (max-width: 480px) {
  .logo-text span { display: none; }
  .sub-form { flex-direction: column; }
  .top-bar-left .date { display: none; }
}

/* Reading Progress Bar */
.reading-progress { position: fixed; top: 0; left: 0; height: 2px; background: linear-gradient(90deg, var(--accent-cyan), var(--accent-violet), var(--accent-amber)); z-index: 10000; width: 0%; transition: width 0.1s linear; pointer-events: none; }

/* Back to Top */
.back-to-top { position: fixed; bottom: 28px; right: 28px; width: 44px; height: 44px; border-radius: 50%; background: var(--accent-cyan); color: var(--bg-primary); display: flex; align-items: center; justify-content: center; font-size: 20px; font-weight: 700; z-index: 998; opacity: 0; transform: translateY(20px) scale(0.8); transition: all 0.35s cubic-bezier(0.22,1,0.36,1); pointer-events: none; box-shadow: 0 4px 20px rgba(0,229,200,0.3); }
.back-to-top.visible { opacity: 1; transform: translateY(0) scale(1); pointer-events: all; }
.back-to-top:hover { transform: translateY(-3px) scale(1.08); box-shadow: 0 8px 30px rgba(0,229,200,0.45); }

/* Skeleton Pulse */
.skel-card { background: var(--bg-card); border-radius: var(--radius-md); border: 1px solid var(--border-subtle); overflow: hidden; }
.skel-card .skel-body { padding: 20px 22px; }
.skel-line { height: 12px; border-radius: 6px; margin-bottom: 10px; background: linear-gradient(90deg, rgba(255,255,255,0.04) 25%, rgba(255,255,255,0.08) 50%, rgba(255,255,255,0.04) 75%); background-size: 200% 100%; animation: shimmer 1.5s infinite; }
.skel-line.w60 { width: 60%; } .skel-line.w80 { width: 80%; } .skel-line.w40 { width: 40%; } .skel-line.w100 { width: 100%; }
.skel-tag { width: 70px; height: 20px; border-radius: 4px; margin-bottom: 14px; background: rgba(255,255,255,0.06); }

/* Card Stagger Animation */
.news-card.fade-in { transition-delay: calc(var(--i, 0) * 60ms); }

/* Search Highlight */
.search-result-item h4 mark { background: var(--accent-cyan-dim); color: var(--accent-cyan); padding: 0 2px; border-radius: 2px; }

/* Stats Pulse Animation */
.source-chip .dot { position: relative; }
.source-chip .dot.online::after { content: ''; position: absolute; inset: -2px; border-radius: 50%; border: 1.5px solid #22c55e; animation: dot-ping 2s cubic-bezier(0,0,0.2,1) infinite; opacity: 0; }
@keyframes dot-ping { 0% { transform: scale(1); opacity: 0.6; } 100% { transform: scale(2.2); opacity: 0; } }

/* Keyboard Focus */
*:focus-visible { outline: 2px solid var(--accent-cyan); outline-offset: 2px; border-radius: var(--radius-sm); }

/* Hero Slide Content Animation */
.hero-slide.active .hero-tag { animation: slideUp 0.6s 0.2s both; }
.hero-slide.active h2 { animation: slideUp 0.6s 0.35s both; }
.hero-slide.active p { animation: slideUp 0.6s 0.5s both; }
.hero-slide.active .hero-meta { animation: slideUp 0.6s 0.65s both; }
@keyframes slideUp { from { opacity: 0; transform: translateY(20px); } to { opacity: 1; transform: translateY(0); } }

/* Nav transition for filter changes */
.news-grid { transition: opacity 0.25s ease; }
.news-grid.fading { opacity: 0.3; }

/* ── AI Summary ── */
.ai-summary-btn { display: inline-flex; align-items: center; gap: 5px; margin-top: 10px; padding: 5px 12px; font-size: 11px; font-weight: 600; color: var(--accent-cyan); background: var(--accent-cyan-dim); border: 1px solid rgba(0,229,200,0.15); border-radius: 5px; cursor: pointer; transition: all 0.2s; font-family: var(--font-body); }
.ai-summary-btn:hover { background: rgba(0,229,200,0.15); border-color: rgba(0,229,200,0.3); }
.ai-summary-btn.loading { opacity: 0.6; pointer-events: none; }
.card-summary { margin-top: 12px; padding: 12px 14px; font-size: 12.5px; line-height: 1.85; color: var(--text-secondary); background: rgba(0,229,200,0.03); border: 1px solid rgba(0,229,200,0.1); border-radius: 8px; border-left: 3px solid var(--accent-cyan); animation: fadeSummary 0.3s ease; font-family: 'Inter', 'Noto Sans SC', -apple-system, 'PingFang SC', 'Microsoft YaHei', sans-serif; word-break: break-word; }
.card-summary .summary-label { font-size: 10px; font-weight: 700; color: var(--accent-cyan); letter-spacing: 0.5px; margin-bottom: 6px; text-transform: uppercase; }
@keyframes fadeSummary { from { opacity: 0; transform: translateY(-4px); } to { opacity: 1; transform: translateY(0); } }
.hero-article .ai-summary-btn { background: rgba(0,229,200,0.15); border-color: rgba(0,229,200,0.25); color: var(--accent-cyan); }
.hero-article .card-summary { background: rgba(0,0,0,0.3); border-color: rgba(0,229,200,0.2); }